Born into a wealthy French bourgeoisie family with financial holdings in Monaco and Germany, she was left with a large inheritance after her father's death.

She died from an embolism a month after giving birth to her only child, Princess Marie Bonaparte.

On 18 November 1880, Blanc married Prince Roland Bonaparte at the Church of Saint-Roch in Paris, despite her mother's opposition.

[citation needed] Her mother-in-law, Princess Pierre Bonaparte, reportedly held the Blanc family in low regard, but supported the marriage due to Marie-Félix's large dowry, which included 8,400,000 francs worth of assets and a reversionary right to a 6,000,000 franc trust which her mother held a life-interest in.

[4] Blanc's death was seven years before her husband succeeded his cousin, Napoléon Charles Bonaparte, as the 6th Prince of Canino and Musignano.