Her acting career includes appearances in television films and Broadway musicals; she has also written several books and helped found the Children's Miracle Network.

Her remaining brothers began performing from an early age as a barbershop quartet and eventually found success on The Andy Williams Show in the 1960s.

"Donny and I were rambunctious playmates, who never gave our mother a moment to rest," Osmond recounted in her book Behind the Smile: My Journey Out of Postpartum Depression.

"[25][21][15] As a duo, Donny and Marie had five more US top 40 singles through 1978: "Deep Purple," "Ain't Nothing Like the Real Thing," "(You're My) Soul and Inspiration," and "On the Shelf.

[18][13] In 1986, Osmond was nominated by the Academy of Country Music for Top Female Vocalist and by the Grammy Awards for her her duet with Dan Seals.

[16] Its three singles reached positions outside the US and Canadian country top 40: "Without a Trace", "Sweet Life" (another duet with Paul Davis) and "I'm in Love and He's in Dallas".

[41][42] Similar to her previous release, all three of its singles (the title track, "Slowly But Surely", "Let Me Be the First") failed to peak in positions inside the US and Canadian country top 40.

Produced by Jason Deere, the project featured collaborations with Olivia Newton-John, Sisqo and Marty Ro (of Diamond Rio).

[16] AllMusic's Stephen Thomas Erlewine rated the album three out of five stars and concluded, "Despite the ambitious cast of characters, it's music that's meant to soothe and comfort old friends, and it certainly succeeds in that regard.

The album featured the Prague Symphony Orchestra and included a cover of "Nessun Dorma", a song she had been performing on stage for years.

"[65] In 1976, programmer Fred Silverman offered Donny and Marie their own television variety series after seeing them perform on The Mike Douglas Show.

[77] In the late 1970s, Marie was considered for the role of Sandy in the film version of Grease, later explaining that the original character was "not a nice girl" and "a lot edgier".

[101][102] "Marie Osmond acting as a cogent adviser is about the most impressive element in 'Celebrity Duets'," wrote Phil Gallo of Variety.

[102] The same year it was reported by Entertainment Tonight magazine that she would join the cast of The Bold and the Beautiful soap opera but scheduling conflicts prevented this from happening at the time.

[117] In 2019, Osmond was announced as the official replacement for Sara Gilbert on The Talk, co-hosting alongside Sheryl Underwood, Carrie Ann Inaba, Sharon Osbourne and Eve.

Osmond left at the same time that producer John Redmann departed the show and it was announced that the pair would collaborate in other television opportunities.

[122] In 2021, Osmond co-starred in a third Lifetime television film titled A Fiancé for Christmas, which told the story of a single woman who makes a fake wedding registry and ultimately finds love in unexpected places.

[126] Osmond was inspired to help sick children after watching how her deaf siblings struggled learning to speak and communicate.

[131][132] Osmond has collaborated and met with hundreds of families since its creation[133] and is part of the program's annual broadcast to raise funds.

[134] "I’m grateful that Children’s Miracle Network has given families access to financial and emotional support, technology, and the best research available, so they don’t have to figure it out on their own the way my mother did," she wrote in 2009.

[145] On Nutrisystems's official website, Osmond is listed under their category labeled "success stories" where she explains her journey with the program.

"The book is easy to read and is written in a conversational tone that makes the reader feel as though Osmond is a friend retelling stories from her life instead of a distant celebrity," highlighted Emiley Morgan.

In 2010, she penned a book of handcrafted project designs called Marie Osmond's Heartfelt Giving: Sew and Quilt for Family and Friends,[157] (Martingale & Company).

[70] When describing her image, the News & Record wrote, "Maybe Marie Osmond needs to get in a brawl in a cool L.A. club, snatch up a Sharon Stone-type film role or start hanging out with Madonna in Miami.

"[163] The Washington Post explained that the Osmond family were "squeaky-clean Mormons who, by all accounts, never indulged in the better-known temptations of showbiz.

[176] The couple remarried on May 4, 2011 in a private ceremony at the Las Vegas Mormon Temple[168] with the bride wearing her dress from their original wedding in 1982.

[181][182][183][184] Osmond and her law firm wrote that Engemann made "repeated defamatory and derogatory comments to third parties, multiple breaches of fiduciary duties, entering into unauthorized commitments, seeking to obtain monies outside the purview of the management agreement and other violations of his obligations.

"[185] "The idea of taking a pill to make depression go away is very appealing, but it sidesteps the cause and treats only the symptoms, like a bandage that only hides an infection.

[189] Osmond started experiencing panic attacks,[190] fatigue,[191] neck pain (which resulted in a hospital visit)[192] and suicidal ideations.

[197] After discussing postpartum depression on The Oprah Winfrey Show, Osmond said that she received "thousands of emails and handwritten letters" from people about their own struggles with the disorder.