Her father, the Duke of Bourbon and First Prince of the Blood, was the eldest surviving son of the Grand Condé.

[citation needed] With the help of her sister Louise Bénédicte, duchesse du Maine, and without the permission of their mother (their father and brother having died by this time), Marie Anne married her distant cousin, Louis Joseph, Duke of Vendôme, a great-grandson of Henry IV of France by his mistress Gabrielle d'Estrées.

The couple wed on 21 May 1710 in the chapel of the Château de Sceaux, Louise Bénédicte's home.

[citation needed] Two days after the marriage, Vendôme left his wife at Sceaux to retire to the château d'Anet.

In 1714 Marie Anne began improvements and extensions to the Hôtel de Vendôme in Paris, where she died in 1718, aged 40.