Her father did not return his wife's affections; instead, he lived as a libertine, engaging in numerous love affairs with members of both sexes.

According to the Duchess of Orléans, born Elisabeth Charlotte of the Palatinate, Madame, Marie Anne was responsible for her own marriage to the Duke of Bourbon as it was she who wanted to prevent her Orléans cousin Marie Louise Élisabeth d'Orléans[2] from marrying the First Prince of the Blood, the most senior male at court after the immediate royal family.

In 1713 at the age of 24, she was married to her maternal cousin Louis Henri, Duke of Bourbon, and Prince of Condé since his father's death in 1710.

After her marriage, Marie Anne took on the style of Her Serene Highness (Son Altesse sérénissime) Madame la duchesse de Bourbon.

Her shape is horrible; she is quite crooked; her back is curved into the form of an S. I observed her one day, through curiosity, when the Dauphine was helping her to dress.

She causes a great many troubles and embarrassments to her relation, the young Princess of Conti, and perfectly understands tormenting folks.

The Duke's joy at the death of his wife will be greatly diminished when he learns that she has bequeathed to her sister, Mademoiselle de La Roche-sur-Yon, all her property; and as the husband and wife lived according to the custom of Paris, 'en communaute', the Duke will be obliged to refund the half of all he gained by Law's bank.