She made her stage debut at the Comédie-Italienne in 1776, at age 13, and remained with the company for almost five decades, creating several roles.

At the age of six she performed couplets in front of Louis XV, accompanied by Madame Dugazon's brother, Joseph Lefebvre, a violinist.

[3][4] In 1776, Desbrosses began her dramatic career, at age 13,[1] at the Comédie-Italienne, rue Mauconseil [fr], in the role of Justine in Le Sorcier[1][3][5] and Colinette in the operetta Clochette.

[10][4] Desbrosses gave her "final" performance in 1823; but at the urging of the authorities, and encouraged by the solicitations of her comrades, she determined to prolong her dramatic career for another six years, until 1829, when she definitively left the theatre,[3][4] and turned to voice teaching.

In 1791, she became the godmother of the son of Joseph Fiévée and his colleague at the Comédie italienne, Adélaïde Françoise Guignard, known as Mademoiselle Lescot[19]