In November 1852 she was engaged at Rome's Teatro Argentina, where she performed in Donizetti's Poliuto, Antonio Cagnoni’s Don Bucefalo and Verdi's I masnadieri and I Lombardi alla prima crociata.

[3] When word of her success in Turin reached Britain, she was invited to sing the British premiere of La Traviata at Her Majesty's Theatre in London, where she appeared for the first time on May 24, 1856.

[3] When the Empress Eugénie heard that she had missed the most talked-about premiere in Paris, she sent word to Calzado, the director of the theatre, and a command performance was arranged for the Emperor Napoleon III and her.

[6] In 1858 Mademoiselle Piccolomini took part both in the first experimental winter season of Her Majesty's Theatre and in the ordinary one, revisiting some of her repertoire roles and presenting for the first time in London La zingara, a highly successful Italian version of Balfe's The Bohemian Girl (with all recitatives set to music), and Verdi's Luisa Miller, which was not however as warmly received.

[9] After her usual tour around the provinces and in Dublin, in October she left for the United States, where she debuted at the New York Academy of Music with her favourite La Traviata, and then moved to Philadelphia and several other large American cities,[Note 3] proposing her repertoire of operas by Verdi, Donizetti, Paisiello and Mozart,[10] and enjoying almost as much success as in London.

[3] In April 1860 she was persuaded by Fabio Campana's entreaties to appear for the last time at Her Majesty's Theatre in the premiere of his Almina,[12] and the following month she married the Marquis Francesco Caetani della Fargna (1824–1906), settling in Florence.

[3] In 1863, however, she heard of the preparations in London for some benefit concerts in honour of Benjamin Lumley, the former impresario of Her Majesty's Theatre, who had launched her international career seven years earlier and who was by then ruined.

Driven by gratitude, she decided on her own initiative to make the long journey to London and took part in the performances which, given the unavailability of Her Majesty's Theatre,[Note 4] had to be held at the Drury Lane.