Pejčinović Burić previously served as a Member of Parliament during its Sixth Assembly (2008–2011), representing the 6th electoral district.

On 26 June 2019, she was elected as the 14th Secretary General of the Council of Europe, defeating Belgium's foreign minister Didier Reynders by 159 votes to 105.

In 1994, she obtained a Master of Science in European Studies from the College of Europe[4] (campus Natolin), after which she went back to work for Končar Inženjering.

In 2008, Pejčinović Burić was elected to the Parliament of Croatia for the centre-right Croatian Democratic Union (HDZ) party, representing the 6th electoral district.

From 2012 until 2013, Pejčinović Burić lectured on the Lisbon Treaty at the seminars of Croatia's State School for Public Administration.

[6] On 26 June 2019, the Parliamentary Assembly of the Council of Europe voted to select the organization's 14th Secretary General, with the candidates being foreign minister Pejčinović Burić and her Belgian counterpart Didier Reynders.