It is graphic novel about a teenage girl who develops romantic feelings towards her female teacher; the secondary storyline is about the suicide of a classmate's ex-boyfriend who may have been gay.

"[8] According to one reviewer, "the expressionistic fluidity of the black and white illustrations serves the purpose of pages of prose;" there is little plot and spare dialogue.

[10] Emiko Superstar, Tamaki's second graphic novel and first with illustrator Steve Rolston, is about a young woman who feels trapped in her suburban life.

As one review says, "this is a story about finding oneself, one's voice, and one's true character amidst the trappings of counter-culture fame.

[15] Tamaki's graphic novel collaboration with artist Rosemary Valero-O'Connell, Laura Dean Keeps Breaking Up with Me, is a queer coming-of-age story about a toxic relationship.

[16] In November 2019, Tamaki wrote a four-part mini-series for Marvel called Spider-Man & Venom: Double Trouble.

[20] Yoshi Yoshitani provided art for the story, which centers Starfire's daughter Mandy Koriand'r, who plans on "moving to France to escape the family spotlight and not go to college" despite her mother's protestations.

In January 2021, as part of DC's Future State event, Tamaki and artist Dan Mora collaborated on Dark Detective, with colors by Jordie Bellaire.

[29] Her 2023 graphic novel Roaming, illustrated by Jillian Tamaki, was shortlisted for the 2024 Lambda Literary Award for LGBTQ+ Comics.