[2] Henner later had co-starring roles in films such as Hammett (1982), The Man Who Loved Women (1983), Cannonball Run II (1984), Johnny Dangerously (1984), Rustlers' Rhapsody (1985), Ladykillers (1988), L.A. Story (1991), and Noises Off (1992).

Her first film appearance was in 1977 sleeper-hit Between the Lines, co-starring then-unknowns Jeff Goldblum, Lindsay Crouse, John Heard, and Jill Eikenberry.

Henner came to prominence with the role of Elaine Nardo in the situation comedy Taxi, portraying a single mother working as a cabbie who aspired to be an artist.

She was the leading lady in the 1982 film Hammett directed by Wim Wenders, produced by Francis Ford Coppola and starring her first husband Frederic Forrest.

Reynolds then asked Henner to join the cast of Cannonball Run II later that year along with Shirley MacLaine and Dom DeLuise.

In 1991, she appeared opposite Steve Martin in L.A. Story as Trudi, a role for which she received a nomination for an American Comedy Award as the Funniest Supporting Female in a Motion Picture.

From 1990 through 1994, she appeared opposite Burt Reynolds in the situation comedy Evening Shade, which also starred Ossie Davis and Hal Holbrook.

Henner starred as the domineering mother of the bride in the Brooks & Dunn video "You Can't Take the Honky Tonk Out of the Girl" in 2003.

She was fired by Donald Trump in the eighth episode but was brought back to help fellow contestant Trace Adkins in the final task of the show.

[citation needed] Henner, who has hyperthymesia, was a consultant for the CBS drama Unforgettable, which starred Poppy Montgomery as Carrie Wells, a woman with the same ability.

In 2018, Henner appeared on the first season of The Neighborhood, a CBS series starring Cedric the Entertainer, Tichina Arnold and Beth Behrs.