Chris was born in Brooklyn, New York, to Jack Miller, an English-Scottish Mennonite and Sylvia Slavin, a Russian Jew.
[7] On February 23, 1958, the New York Daily News chose Chris as that week's "Typical American Girl."
[9] Prompted by the discovery that her birth name was already registered with Actors Equity, Miller devised a stage name simply by shortening her then-married name, Christopoulos.
[10] She made her film debut in Love with the Proper Stranger (1963), co-starring with Natalie Wood and Steve McQueen.
[11] In 1965, Chris was an under study for the roles of Agnes Graham and Sylvia Goldman in the original Broadway production of The Family Way.
[12] Chris appeared in the romantic drama film John and Mary (1969), co-starring with Dustin Hoffman.
[7] In 1972, Chris briefly played the role of Edie Hoffman on the ABC soap opera All My Children.
[19][20] In May 1972, she was cast in the contract role of Wanda Webb on the ABC soap opera One Life to Live.
[24] She played Faye Stone in the television film Strike Force (1975), co-starring with Richard Gere.
[14] Chris appeared in the film American Stories: Food, Family and Philosophy (also titled Histoires d'Amerique) (1989).
[10] In March and April 1992, Chris appeared in Barefoot in the Park at the Valley Forge Music Fair.
[38] Soap Opera Digest reported in January 1994 that Chris would be leaving her role on One Life to Live.
[27] She played Phyllis in The Great New Wonderful (2005), a comedy film about New Yorkers living in the city after the September 11 attacks.
[14] In March 2010, she appeared in Sin at the Baruch Performing Arts Center's Rose Nagelberg Theatre.
[48] In July 2024, Chris played serial killer Nannie Doss in a solo reading of The Giggling Granny at the Southampton Cultural Center.