The squadron was relocated again to Marine Corps Base Camp Pendleton, California in October 1965.

In late May 1967, MACS-4 departed San Diego onboard the USS Hermitage (LSD-34) and landed in Danang, Republic of Vietnam.

The site also provided excellent line of sight to United States Seventh Fleet ships operating in Yankee Station in the Gulf of Tonkin.

[7] The squadron departed Vietnam embarking on the USS Alamo (LSD-33) on January 31, 1971 to head back to MCAS Santa Ana, California.

The squadron was decommissioned the same day it left Vietnam and was reactivated on June 15, 1971 at Marine Corps Air Station Futenma in Okinawa, Japan remaining part of MACG-18.

Even though MACS-4 departed Vietnam on January 31, 1971 it maintained a small detachment of twenty Marines on top of Monkey Mountain to man the AN/TYQ-3 - Tactical Data Communications Central (TDCC).