VMO-6 flew its OY-1 aircraft on a variety of missions, including artillery spotting, message pickups, photo reconnaissance and medical evacuations in litter equipped OY-ones.

The squadron served in a variety of liaison roles and flew very dangerous missions often under intense ground fire from the communist forces.

[5] In August 1950, HO3S-1 helicopters and pilots from HMX-1 at MCAF Quantico, Virginia joined the squadron's eight OY-2 Sentinels and VMO-6 departed the United States in July 1950 as part of Marine Aircraft Group 33.

For the first four days of the battle, until an expeditionary airfield was completed at Hagaru-ri on 1 December, helicopters from VMO-6 were the only aircraft able to evacuate the wounded taking 152 injured south to Hungnam.

After training by the Army, the Hueys were converted to primarily a gunship role and the majority of the UH-1's missions were providing close air support to infantry and recon units.

While providing support to Marines at the Battle of Hill 488 on the night of 15 June 1966, the squadron's new commanding officer, Major William J. Goodsell, was killed when his UH-1E was shot down.

July 1968 saw the squadron get its first fixed wing aircraft since World War II when they took possession of a few Cessna O-1C & 0-1G Birddogs that were used for directing artillery and air strikes.

The squadron flew in support of Marines at Khe Sanh, Con Thien, Lao Bảo, Đông Hà, Gio Linh, The Rockpile, Vandegrift Combat Base, the Ben Hai and Firebase Argonne.

Their biggest action came during Operation Dewey Canyon from 22 January – 18 March 1969 where the Marines sought to engage Communist forces near the Laotian border.

From there they participated in exercises from such places as Cubi Point in the Philippines, Atsugi, Japan; Taegu, Korea; and the Republic of China.