Mario Andrés Hamuy Wackenhut (born 1960) is a Chilean Astronomer and Professor of Astronomy at the University of Chile and Cerro Calan Observatory.

Hamuy was a student in astronomy and physics at the University of Chile working with Jorge Melnick.

In graduate school at the University of Arizona at the Steward Observatory working with Professor Phil Pinto, he changed his focus to the study of core collapse supernovae, in particular using Type II supernovae to measure geometric distances using the Baade-Wesselink method, also called the expanding-photosphere method (EPM).

Asteroid 109097 Hamuy, discovered by Spanish astronomer Rafael Ferrando at the Pla D'Arguines Observatory (941) in 2001, was named after him.

[13] He is also the president of CONICYT, the Chilean government's scientific research agency[14] and a recipient of the 2016 TWAS Prize.