Mario Sampirisi (born 31 October 1992) is an Italian professional footballer who plays as a full-back for Serie B club Reggiana.

[3] Samprisi made his Serie A debut for Genoa on 22 January 2012 in a game against Palermo when he came on as a substitute in the 45th minute for Juraj Kucka.

[11] On 10 July 2015 Vicenza re-signed Sampirisi in a temporary deal, with an obligation to sign him outright.

On 15 December 2020, Sampirisi scored a brace in the Serie B against Virtus Entella, helping Monza win 5–0.

[14] Sampirisi helped Monza gain promotion to the Serie A for the first time as their captain in 2021–22.