As a union station it served several train lines: the Chesapeake and Ohio Railway, Cleveland, Cincinnati, Chicago and St. Louis Railway or CCC & St. L. (acquired in 1906 by the New York Central Railroad), and Erie Railroad (and its successor Erie Lackawanna Railroad).

It was built in 1902 (opening on July 31),[2] it featured marble walls and patterned mosaic tiles on the floor.

In 1923, it was the last stop on President Warren Harding's funeral train.

It had its last long-distance train in 1971 with the end of the Chesapeake & Ohio's connector line to the George Washington.

[4] About 60 CSX and Norfolk Southern freight trains pass by each day.