[5] Marge was friends with Oz author Ruth Plumly Thompson and illustrated her fantasy novel King Kojo (1933).

In 1934, The Saturday Evening Post requested Buell to create a strip to replace Carl Anderson's Henry.

The first single-panel installment ran in the Post on February 23, 1935; in it, Lulu appears as a flower girl at a wedding and strews the aisle with banana peels.

She traveled to New York to meet with Paramount executives and tour the animation facilities, and there was introduced to William C. Erskine, who became her business representative.

[7] Thereafter, Little Lulu was widely merchandised,[8] and was the first mascot for Kleenex tissues;[5] from 1952 to 1965 the character appeared in an elaborate animated billboard in Times Square in New York City[9] designed by Artkraft Strauss.

Little Lulu comic books, popular internationally, were translated into Arabic, Dutch, Finnish, French, Japanese, Norwegian, Portuguese, Spanish, Swedish and Greek.

The two reached a compromise in their career ambitions, in that the husband agreed to turn down promotions that would result in relocation, and the wife would keep her creation enough in check that she would be available for her children.

[7] She also shied away from politics, and resisted requests from her sons to include progressive elements such as a black playmate for Lulu or overtly feminist themes.

The papers include a collection of fan mail, comic books, scrapbooks of high points in Lulu's history and a complete set of the newspaper cartoons.