Mark DeSantis (born June 16, 1959) is an American tech entrepreneur and CEO of Bloomfield Robotics and an adviser to MIR Ventures in Palo Alto.

He was CEO and cofounder of RoadBotics, an AI-based product that monitors and manages roadway infrastructure.

Previously, Mark was CEO of Think Through Learning, a venture-backed online tutoring company and US Managing Director of ANGLE Technology, PLC, a UK-based venture capital firm and consultancy.

DeSantis was previously the Director of Government Relations for Texas Instruments, Inc. in Washington DC.

DeSantis headed a GOP-led group called "Citizens for Democratic Reform" that supported the elimination of Allegheny County row offices.