It gave its name to the nearby Mark Lane tube station, which was opened in 1884, renamed Tower Hill in 1946, and closed in 1967.

At its northern end, Mark Lane originates as a two-way side-road off Fenchurch Street, leading to Dunster Court, the home of the Worshipful Company of Clothworkers.

[3] According to the antiquarian John Stow, writing at the end of the 16th century, the name of the lane is derived from a former cattle market or "mart" once held there.

[8] Permission having been granted by Parliament, they established their new exchange, also in Mark Lane, immediately alongside the old; it was designed by George Smith in the Greek Revival style, and opened in 1828.

In 1882, the Old Exchange was largely demolished and replaced by a far larger building, designed by Edward I'Anson in the Italianate style.