After his playing career, he worked for the NFL Players Association (NFLPA) and then as a trial lawyer for the United States Department of Justice.

Murphy's hiring coincided with quarterback Brett Favre leaving the team and Aaron Rodgers taking over.

Murphy has only hired one new head coach and one new general manager in his tenure: Matt LaFleur and Brian Gutekunst, respectively.

He also led the effort to purchase land adjacent to Lambeau Field and redevelop it into the Titletown District, a mixed-use development that supports tourism and provides year-around activities to local residents.

In 2022, Murphy announced his intention to retire in 2025 when he turns 70 years old, with the Packers selecting Ed Policy as his successor.

That year, he was named to the Eastern College Athletic Conference (ECAC) Division I football all-star squad.

[5] During his college football career, he intercepted over 10 passes and was respected enough that opposing teams often did not throw the ball in his direction.

He signed shortly thereafter with the Washington Redskins as an undrafted free agent, primarily to serve on Special teams.

[1][10] Murphy was co-captain of the 1982 Washington Redskins team that won Super Bowl XVII during the 1982 strike-shortened NFL season.

[10] During the second half of the Super Bowl, Murphy recorded a critical interception that helped prevent the Miami Dolphins from opening up a larger lead.

[4] Many, including Murphy, felt that his prominent role in the players' strike led to his eventual release by the Redskins.

During his three years at the NFLPA, he worked on a player counseling program, drug testing, and collective bargaining and developed the agent certification system.

Student-athletes at Northwestern were tied for the best graduation success rate in the country in 2007, Murphy's last year in charge of the program.

[3] In 2023, Murphy was named as a defendant in two lawsuits by former football players related to a hazing scandal that occurred during his tenure as athletic director.

[30][31] The Packers had just come off an overtime loss to the New York Giants in the NFC Championship Game[32] and shortly thereafter, quarterback Brett Favre announced his retirement.

[40] Rodgers continued to improve and lead the team to success, with the 2009 season beginning a string of eight straight playoff berths.

[43] This victory likely made Murphy the first person to win a Super Bowl both as a player and as a team's chief executive.

[56] The Packers had been slowly purchasing property adjacent to Lambeau Field with the intention of developing it to provide additional year-round revenue streams and activation of the area during the off-season.

[62] Murphy promoted Brian Gutekunst, who was the Packers' director of player personnel, to the vacant general manager position.

[74] Murphy also advocated for the ability for players to opt out of the season without impacting their contracts, a rule that was ultimately implemented.

[75] Additional safety measures included enhanced testing, expanded rosters and changes to how soon players could return off of injured reserve.

[79] Approximately 190,000 new shares were sold, raising about $64 million to help fund improvements to the Lambeau Field concourse, new video boards and other infrastructure projects.

For a couple seasons, Rodgers began publicly discussing retirement, his future with the Packers and the possibility of ending his career with another team.

However, in March 2022, Murphy signed Rodgers to a large contract extension and publicly committed to him being the starting quarterback moving forward.

[41] Murphy noted that in his remaining years as president he would like to see Lambeau Field renovations completed, the Titletown District built out and continued on-field success.

Policy served as the team's general counsel and chief operating officer, roles he would continue in until Murphy's tenure formally ended in July 2025.

They are active in numerous local organizations, including multiple schools, churches and youth sports leagues.

[3] Financially, the Murphys have donated to organizations like the Milwaukee Public Schools Foundation, We All Rise Green Bay, Urban Triage and Maroon Calabash.

Murphy also pledged to donate $250,000 to "causes in Wisconsin that support social justice and racial equality" following the murder of George Floyd and subsequent protests.

[93] In 2023, Murphy and his wife purchased the Maxwelton Braes Golf Course in Door County, Wisconsin, with the goal of preserving it and preventing it from being developed into housing.