[3] His father Gene Radice was a well-known recording engineer who worked with Jimi Hendrix, Velvet Underground, Lovin' Spoonful, Janis Ian, the Four Seasons, Cowsills, Mamas & the Papas, The Tokens, Vanilla Fudge, and many more.

[4] Mark Radice began writing songs, after teaching himself guitar while listening to Beatles albums, at the age of seven.

"[8] As a writer for EMI Publishing in the 1970s, he collaborated with artists such as Michael Bolton, Eddie Money, Dave Edmunds, Barbra Streisand,[9] Barry Manilow, Johnny Mathis, Helix, Cheap Trick, Aldo Nova, Deodato, Phyllis Hyman, Jetboy, Box of Frogs, Gene Simmons, Shark Island, Jennifer Rush, and The Muppets.

[2][10] In a chance encounter in a Los Angeles hotel lobby, Radice ran into Steven Tyler who asked him to tour with Aerosmith on keyboards and backing vocals.

[2] Radice was introduced to Jim Henson by Phil Ramone and wrote 50-plus songs for The Muppets franchise over eight years, including for the film Elmo's Christmas Countdown.