[8] Tuan had no desire to pursue a musical career but was encouraged by his friends and family who told him it was a good opportunity and thus, he gave it a try.

[13] Learning to sing, rap and dance, and performing on a stage as a trainee, inspired him to pursue the idol life and to become a singer.

[8][9] In 2012, Tuan made a cameo in the first episode of Dream High 2 as a backup dancer alongside JB and Jinyoung, who later became members of Got7 with him.

He appeared in the fourth episode of Mnet's 2013 reality-survival program WIN: Who is Next, which presented iKon and Winner members, who at the time were still trainees under YG Entertainment.

[19] With Got7's third studio album Present: You, Tuan released his first Korean solo song "OMW" featuring fellow member Jackson Wang;[20] an accompanying music video was published on September 13, 2018.

[27][28] On February 10, 2018, Tuan, along with fellow member BamBam, held the "Project Blur" fan meeting in Thailand at MCC Hall The Mall Ngamwongwan, whose tickets sold out in a minute.

[41] From June 15 until August 28, 2020, Tuan appeared on eight episodes of Huya Super Idol League Season 10 as "Gamer Mark".

[45] The opening of his company Mark Tuan Studio in Beijing was announced on February 7 with focus on his solo Chinese activities and promotions.

[53][54] In the second half of the year, Tuan sang "Never Gonna Come Down" with Bibi for the movie Shang-Chi and the Legend of the Ten Rings.

[65] In October and November, Tuan subsequently embarked in his first solo tour and performed in 15 cities across North America;[66][67] the Asian leg started in Bangkok and Khon Kaen in April 2023.

[72] Growing up in the US and coming from a Taiwanese family, Tuan can speak both English and Mandarin Chinese, as well as having learned Korean and Japanese.

[73] In December 2018, Tuan suffered from a leg injury while practicing martial arts tricks for the JYP Nation stage on 2018 KBS Song Festival and could not perform at the event or at later schedules including the fifth anniversary fan meeting for Got7, therefore he stayed seated for most of the concert.

[79] On May 31, Tuan donated $7,000 to the George Floyd Memorial Fund and the Black Lives Matter movement in light of events in the US.

[84][85] In September 2024, he partnered with Siam Center to auction some of his exclusive unseen photos to raise money to help flood victims in Thailand.