[2] During early Islamic rule (7th–10th centuries), Makisin was a town in the district of Diyar Rabi'a with a bridge that crossed the Khabur River.

[3] In the late 680s, numerous Christian Taghlib tribesmen were killed in an ambush at Makisin by the Sulaym tribe as part of the long-running Qays–Yaman feud.

[4] Obadiah the Proselyte visited Makisin in the 12th century and found there a Jewish community and synagogue, which then housed the Codex Sassoon.

[6][7] Having gained control of the town, the al-Nusra Front were driven out the following year by Islamic State in the Battle of Markada.

[8] US-led Coalition airstrikes against ISIL targeted the town in September 2017, with many casualties, including Iraqi refugees, reported.