Markkleeberg-Großstädteln is a railway station in Markkleeberg, Germany.

The train services are operated by Deutsche Bahn.

Since 15 December 2013 the station is served by the S-Bahn Mitteldeutschland.

With the integration of Großstädteln into the municipality of Markkleeberg on 1 November 1937, it was renamed Markkleeberg-Großstädteln.

From 1879 to the cessation of passenger traffic in 2002, Großstädteln was also a stop on the Leipzig-Plagwitz–Markkleeberg-Gaschwitz railway.