He was a Minister of Foreign Affairs of Yugoslavia and Chairman of the League of Communists of Serbia.

Nikezić was born in Belgrade to a Serb father, Petar, and a French mother, Suzanne.

He was a member of the Yugoslav Partisan army from 1941, during World War II.

After the war, he served as Yugoslav ambassador to Egypt, Czechoslovakia and the United States of America.

In 1972, he was dismissed from the office under the charge of being too "liberal" and "anarcho-liberal", alongside Latinka Perović and other Serbian high-officials.