[2] In 1993, Sokoloff (then aged 12) began pursuing an acting career when she was cast as Gia Mahan in the popular ABC sitcom Full House.

She was originally in-mind to play Topanga Lawrence on ABC's Boy Meets World, and had even filmed a few scenes; however, the part was subsequently given to Danielle Fishel.

She also made a guest appearance in an episode of Burn Notice, where she played Melanie, working undercover as a receptionist at a Miami art gallery whose owner had murdered her character's father.

Sokoloff also has starred in several movies, including Whatever It Takes, The Climb, The Tollbooth, Dude, Where's My Car?, Sugar & Spice and Love on the Side.

In 2008, Sokoloff starred alongside Paul Campbell, Andy Griffith, Doris Roberts and Liz Sheridan in the romantic comedy Play the Game.