[4] Marleen Lohse began acting in television series and films at the age of 12, and played the character Julia "Hexe" Clement in the children's series Die Kinder vom Alstertal from 1998 to 2002.

After completing school, Lohse continued acting appearing in Wilde Jungs (2004) and in the television series Stolberg and Leipzig Homicide and in the Tatort episodes Roter Tod (2007) and Schatten der Angst (2008).

She also appeared in the television films Mordshunger (2008), Das tapfere Schneiderlein (2008), Das blaue Licht [de] (2010) and Tsunami – Das Leben danach and in the cinema films Vollidiot (2007), Diamantenhochzeit (2009), Wedding Fever in Campobello (2009), Résiste – Aufstand der Praktikanten (2009), 205 – Room of Fear (2011) and No Sex Is No Option [de] (2011).

[7] Lohse is a songwriter for the musical duo Unsereins,[10][11] in which she plays guitar and sings with Julius Hartog.

[13] Marleen Lohse's parents run a hairdresser salon in St. Georg, Hamburg.