Brad Anderson won the National Cartoonists Society's Reuben Award for Newspaper Panel Cartoon in 1978,[10] and the George Arents Pioneer Medal for Syracuse University alumni in 1999.

Attempts to cancel Marmaduke have drawn protest, such as those by readers of The Toronto Star in 1999,[12] of the Sarasota Herald Tribune in 2007,[13] and of the Chicago Sun-Times in 1986.

"[17] For example, a blog called "Joe Mathlete Explains Today's Marmaduke"[18] deconstructs the strip to offer an alternative explanation for what is happening in the drawing.

A live-action Marmaduke movie, in which the Winslows and their dog move from Kansas to California, was released on June 4, 2010 and received generally negative reviews from critics.

[25] The film featured Pete Davidson as Marmaduke, J.K. Simmons as Zeus, Brian Hull as Guy Hilton, Shelby Young as Shantrelle, and David Koechner as Phil Winslow.