[6] Maropitant has been used in acute cases of rapid or labored breathing to prevent vomiting that could lead to aspiration pneumonia.

[15] It has been given in combination with a benzodiazepine to cats prior to stressful events (such as a veterinary visit) to possibly relieve hypersensitivity.

[16] When compared to other antiemetics, maropitant has similar or greater effectiveness to chlorpromazine and metoclopramide for centrally mediated vomiting induced by apomorphine or xylazine.

[15] It alleviates visceral pain and has been found to reduce the amount of general anesthesia (both sevoflurane and isoflurane) needed in some operations.

[5] Maropitant is only indicated for dogs at least 16 weeks old, as some very young puppies suffered bone marrow hypoplasia (incomplete development ).

[13][18] It is not recommended to give maropitant for more than five consecutive days, as it tends to accumulate in the body due to one of the liver enzymes responsible for its metabolism, CYP2D15, becoming saturated.

[22] Maropitant is safer than other antiemetics used in veterinary medicine, in part because of its high specificity for its target and thus not binding to other receptors in the central nervous system.

[14][20] While there is no pain related to the intravenous administration of maropitant, pushing a dose in too quickly can temporarily reduce blood pressure.

[22] Signs of maropitant overdose include lethargy, irregular or labored breathing, lack of muscle coordination, and tremors.

[17][24] By virtue of working at the last step in triggering vomiting, it can prevent a broader range of stimuli than most antiemetics can.

[11][12] Repeat dosing of maropitant eventually saturates CYP2D15, causing the drug to accumulate due to reduced clearance.