[7] From 19 April 2014 to 25 May 2014, José Manuel Barroso was an Acting Commissioner in Šefčovič's stead while he was on electoral campaign leave for the 2014 elections to the European Parliament.

[9] In July 2015, he brokered an agreement between fifteen countries from central, eastern and southeast Europe to speed up the building of gas links, improve security of supply, reduce their reliance on Russia and develop a fully integrated energy market.

[11] In September 2019, newly-elected president of the European Commission Ursula von der Leyen named Šefčovič as vice-president for interinstitutional relations and foresight.

[13] In 2023, von der Leyen appointed Šefčovič to replace Frans Timmermans as European Commissioner for Climate Action.

The position of European Commissioner for Climate Action was also assigned to Šefčovič on a temporary basis until a permanent successor has been chosen by the Netherlands.

[citation needed] During his presidential campaign, Šefčovič repeatedly spoke against legislative changes which would improve the status of LGBT rights in Slovakia, strongly opposing both civil partnerships and same-sex adoptions.

[21] Šefčovič has criticized Angela Merkel's actions in this area, labeling her "latest decisions which opened door to mass migration" as something that was not "thought-out very well".

[25] When asked about the Venezuelan presidential crisis, Šefčovič refused to identify either Nicolás Maduro or Juan Guaidó as legitimate president, stating that "leaning on one or the other side might worsen the situation".