However, the whiskey now known as Jameson Irish Whiskey was not produced at this distillery, but at the separate enterprise run by John Jameson at the nearby Bow Street Distillery.

Initially a small undertaking, with an output of just 30,000 gallons per annum,[1] the distillery expanded over time, and by the time Alfred Barnard, a British historian visited the distillery in the 1880s, it had grown to cover some 14 acres.

[1] In his book, The Whisky Distilleries of the United Kingdom, Barnard described Marrowbone Lane as having some of the biggest distilling equipment in the world, including two mash tuns with capacities in excess of 100,000 gallons, which were the "said to be the largest in the United Kingdom".

[1] At its peak, the distillery was the second largest in Dublin (then one of the world's largest whiskey distilling centres), with an output of 900,000 gallons per annum, and a staff of 200, including 30 coopers.

Although, the amalgamated company had a potential production capacity of 3.5 million gallons per annum, it continued to endure severe financial difficulties, in particular, following the loss of both the American and British Commonwealth export markets during prohibition and the Anglo-Irish trade war in the 1920s.