Guill was a prominent quarterback and end on John Heisman's Georgia Tech Golden Tornado football team.

Guill was a starter for the school's first national championship team in 1917, which outscored opponents 491 to 17.

Guill played as quarterback for much of 1919, shifted to end in the latter part of the year for newcomer Jack McDonough.

He was killed in an automobile collision on the New London-New Haven highway near Guilford, Connecticut on May 11, 1931.

At the time of his death he was connected with the American Moistener Corporation of Charlotte, North Carolina.