He has previously played in MLB for the Minnesota Twins, Boston Red Sox, Texas Rangers, Pittsburgh Pirates, and San Diego Padres.

On June 30, Pérez made his first major league start, pitching 5 and a third innings and striking out five while only giving up two runs in a 7–2 win over the Oakland Athletics.

On August 1, Pérez was optioned to Triple-A Round Rock to make room for pitcher Ryan Dempster.

[3] Pérez went into 2013 spring training competing for the fifth spot in the Rangers rotation (which eventually went to Nick Tepesch), but on March 3 in a start against the Mariners, he broke his pitching forearm when it was hit by a line drive by Brad Miller.

[7] On November 7, 2013, Pérez signed a four-year, $12.5 million contract with the Rangers that included three club options, keeping him under team control through 2020.

On May 19, 2014, Pérez underwent Tommy John surgery to repair a partially torn UCL in the aforementioned elbow, which kept him out of action for the remainder of 2014.

[citation needed] Pérez had his first major league hit on July 15, 2016, against Chicago Cubs' pitcher Kyle Hendricks.

[17] Overall with the 2020 Red Sox, Pérez appeared in 12 games (all starts), compiling a 3–5 record with 4.50 ERA and 46 strikeouts in 62 innings pitched.

[18] On November 1, the Red Sox declined to exercise their $6.85 million option for Pérez for the 2021 season, paying him a $500,000 buyout and making him a free agent.

[24] Overall during the regular season, Pérez made 36 appearances (22 starts) for Boston, compiling a 7–8 record with 4.74 ERA; he struck out 97 batters in 114 innings.

[7] In the postseason, he made four relief appearances against Houston in the American League Championship Series, allowing five runs in three innings.

[26] On May 29, Pérez took perfect game bid versus the Houston Astros into the seventh inning until Chas McCormick led off with a double.

[33] Pérez features a four-seam fastball that is regularly clocked at 93 miles per hour (150 km/h), a sharp breaking curveball, and a change-up.