In addition to writing and editing several journals, she serialized short stories and poems in newspapers such as the Chicago Tribune, the Detroit Free Press, and the Los Angeles Herald.

[1] In 1854, she immigrated to Boston, Massachusetts[4] and two years later on April 9, 1856, Woodworth married Robert Weir Rayne in Roxbury.

[11][15] After reporting on the 1874 wedding of Frederick Grant, son of President Ulysses S. Grant,[11] and the wedding of General Philip Sheridan,[1] Rayne interviewed and wrote a piece on Mary Todd Lincoln's confinement in a mental institution, which led to Lincoln's release.

[1][12][16] In addition, she published several novels, including Jenny and Her Mother (1867), Fallen Among Thieves (1876) and Against Fate: A True Story (1876).

During this time, she interviewed such celebrities as President Grover Cleveland, Henry Wadsworth Longfellow and John Greenleaf Whittier.

[11][21][22] She offered courses in developing a literary style, manuscript preparation, use of language, reporting and other writing skills[21] to provide professional instruction to women, who were typically denied higher education opportunities.

[23] Rayne was a member of the National Woman's Press Association and served as the Michigan vice president of the organization in 1886.