She has appeared in several feature films, including Superbad (2007), The Last House on the Left (2009), Dead Before Dawn (2012), and Battle of the Sexes (2017).

MacIsaac was born and raised in Charlottetown, Prince Edward Island,[1] the youngest of three girls; her mother Irene was one of twelve.

[7] In a 2007 Entertainment Weekly article, she stated she has been inspired by Julia Roberts from the age of four and was self-described as "obsessed".

[8] In late 2012, MacIsaac began a main role on the NBC comedy 1600 Penn as the president's eldest daughter, Becca.

[9] In a 2012 interview with the CBC Radio series Island Morning, she did reveal that 1600 Penn was her last audition before she considered returning to Canada.