Matoula has a career-high singles ranking by the Women's Tennis Association (WTA) of 305, achieved on 6 November 2023.

She has won two titles in singles and two in doubles at tournaments of the ITF Women's World Tennis Tour.

Matoula has competed for Greece in the Billie Jean King Cup where she has a win-loss record of 1–0 in singles and 1-1 in doubles.

[2][3] She attended college at the University of Tulsa (2015–2019) and graduated with a Bachelor's degree of Accounting.

[4] Matoula made her WTA Tour main-draw debut as a qualifier at the 2023 Transylvania Open, losing in the first round to Patricia Maria Țig in a three set match lasting more than three hours.