Diño first rose to prominence as the barangay captain of San Antonio, Quezon City for 13 years, during which he became a vocal advocate for the stepdaughter of Leo Echegaray, who was executed for raping her, in 1999.

[3] On the final day of the filing of candidacies for the 2016 Philippine presidential election on 26 October 2015, PDP–Laban nominated Diño, its deputy secretary-general, as its candidate for president.

After Duterte won the presidency, he appointed Diño to become Chair of the Subic Bay Metropolitan Authority on 23 September 2016.

He was also the father-in-law of singer and former child star Ice Seguerra, whom Liza married in the United States in 2014 and was also appointed by Duterte as chair of the National Youth Commission.

[10][11][12][2] In July 2023, Liza disclosed that her father had been suffering from stage IV lung cancer for more than a year.