On 18 June 2004, Gerber was traded to the Carolina Hurricanes in exchange for Tomáš Malec and a third-round pick in the 2004 NHL Entry Draft.

Gerber entered the 2006 Stanley Cup playoffs as the Hurricanes' starting goaltender, but he struggled in the team's opening series and was replaced by rookie Cam Ward, who had been his backup for most of the season.

Gerber entered the 2008–09 season in that role, but his uneven play continued and he was eventually supplanted by the newly signed Alex Auld.

[7] On 4 March 2009, Gerber was claimed off waivers by the Toronto Maple Leafs to replace goaltender Vesa Toskala, who was scheduled for season-ending surgery.

[9] During the off-season, Gerber signed a contract with Atlant Moscow Oblast of the Kontinental Hockey League (KHL), coincidentally the same team that fellow former Senators goaltender Ray Emery played for the previous season before returning to the NHL in 2009.

Gerber's neck injury was initially thought to be a compression fracture of a cervical vertebra and it was believed that he would miss upwards of six months.

Picking up where he left off in late November, Gerber stopped 34 shots in a 2–1 shootout win over the Nashville Predators on 1 March, improving to a 3–0 record with Edmonton.

[17] Playing 42 games, he finished the 2011–12 season ranked fifth in the save percentage with .928 and seventh in goals against average (GAA) with 2.18, although Växjö failed to qualify for the playoffs.

During his playing career, Gerber was a mainstay on the Switzerland national team, having represented his country in eight IIHF World Championships and two Winter Olympics since 2000.

Switzerland failed to medal in any of these tournaments, their highest finish being fifth in 2010, though their play has seen their IIHF World Rank increase from ninth in 2003 to seventh in 2010.