In 1964, Wygod became involved with Computer Sciences Corporation (CSC) in California, run by founders Roy Nutt and Fletcher Jones.
In the 1970s he shifted his focus to the burgeoning health care industry, buying Glasrock Medical Services in 1977 and after five years of solid growth, sold it for a large profit.
Wygod was Chairman of WebMD and of HLTH Corporation, an Elmwood Park, New Jersey, technology company providing healthcare information services.
Fletcher Jones owned Westerly Stud Farms near Santa Ynez, California and was involved in horse racing for several years until his untimely death in 1972.
A member of The Jockey Club, Martin Wygod and his wife Pamela began devoting more time to their horses and became major players in Thoroughbred racing.