The series re-imagines the comic books' main characters Martin Mystery and Diana Lombard as teenage stepsiblings attending Torrington Academy,[1] a boarding school located in the city of Sherbrooke, Quebec.

Their allies at The Center include Billy, a small, green-skinned alien who is one of Martin's best friends; and Java, a caveman from 200,000 years ago, who works as a janitor at Torrington Academy and is the arm of the group.

Martin's vast knowledge of the supernatural and his remarkable intuition make him a valued agent of The Center, and compensate for his huge ego and his clumsy attitude.

Additional channels in Europe included SVT1 and SVT Barnkanalen in Sweden, NRK Super in Norway, Yle TV2 in Finland, GMA Network[4] and Q (now known as GTV) in the Philippines, VT4 in Belgium and ZigZap in Poland.

MBC 3, Ajyal TV, and ART 3 broadcast this show in Arabic throughout the Middle East, with the voice talents of Mo'awad Ismail as Martin and Mariam El Khesht as Diana.

Background characters resembling Martin, Diana, and Marvin have appeared on other series produced by Marathon and Image, such as Team Galaxy, Totally Spies!, and The Amazing Spiez!.