Afterward, he worked on various position at Entreprise d’état d’assurances et de réassurances (SIRIRI) in Bangui from 1988 to 1995.

[4] Ziguélé was appointed as Prime Minister on 1 April 2001 by President Ange-Félix Patassé,[5][6] replacing Anicet-Georges Dologuélé.

[7] Ziguélé left office when rebel leader François Bozizé took power upon capturing the capital, Bangui, on 15 March 2003.

[5] Ziguélé was initially barred from running in the 2005 presidential election, along with six other candidates, by a court ruling on December 30, 2004.

[11][12][13] On June 23, 2007, at the end of the MLPC's third ordinary congress,[13] Ziguélé was elected to a three-year term as President.

[15] In October 2021, The COD-2020 coalition, Crépin Mboli-Goumba’s Patrie party and Martin Ziguélé’s Central African People’s Liberation Movement withdrew their representatives from the organizing committee and denounced “a desire to sabotage the Dialogue”.