He started his musical career by playing bass in a Dutch punk rock band when he was 14.

In 1989, he moved to Los Angeles and played with Thelonious Monster and the Too Free Stooges.

In 1992, he joined Peter DiStefano, Stephen Perkins and Perry Farrell to form Porno for Pyros.

LeNoble has worked, recorded, toured, or performed with artists including Jane's Addiction, the Cult, Dave Gahan,[1] Scott Weiland, Mark Lanegan, Soulsavers, Daniel Lanois, Maria McKee, Sarah McLachlan, Layne Staley, Tom Morello, and Josh Klinghoffer.

LeNoble and Applegate became engaged on Valentine's Day 2010,[2] and married in February 2013.