Between combat missions, players manage their upgradeable base of operations called "The Abbey" which they can walk around in a third-person view to explore the grounds and interact with other heroes.

Other villains include the devil Mephisto, the mutant Sabretooth, Dracula and Chthon, as well as fallen versions of Venom, Hulk, Scarlet Witch, and the Hunter.

Six months later, a star called the "Midnight Sun" approaches Earth, destabilizing magic and heralding the return of Lilith's master, Chthon.

Doctor Strange and Tony Stark attempt to get a page of the Darkhold called the Parchment of Power from Johnny Blaze, but he refuses.

After being alerted to magic converging at the Sanctum Sanctorum, the two are joined by Carol Danvers and return to aid Wanda Maximoff in fighting Lilith and a Hydra squad until Strange can create a mystic shield to repel them.

He, the Hunter, and Blade travel to the Sanctum, where they learn Lilith has enthralled Venom to help her destroy the shield and abduct Maximoff.

While stopping an attack by Lilith's demons, the heroes recruit Wolverine and fashion a new suit for the Hunter so they can bypass the Hydra base's mystic defenses, use the accelerator to destroy the Parchment, and free Maximoff.

Blaze sacrifices himself to destroy the Parchment via the accelerator and free Maximoff, but Banner uses the device to transform into a smarter, demonic Hulk.

The heroes track Hydra and Lilith to her tomb, where Reyes tries to seal her and the Hulk in a cave before they can restore the Darkhold, but she unleashes demons around the world.

After defeating Crossbones and his forces, the heroes steal a dagger imbued with Chthon's power while Maximoff and the Hunter subdue and free Banner.

Realizing she and her child were corrupted by the grimoire, Lilith sends the heroes back to the Abbey while she, the Hunter, and Chthon's realm are consumed by the Darkhold.

After Sin betrays Hydra, steals the Magna Corrigo, and unleashes a group of infected "vampyres", the Hunter offers Deadpool sanctuary at the Abbey to protect him from Doom over the heroes' protests.

As the vampyres convert Hydra troopers and attack New York, Spider-Man convinces Blade to help him recruit a mutual acquaintance of theirs, Michael Morbius.

Nonetheless, while fighting off Dracula and his empowered forces, the heroes discover the vampyres diluted Morbius' sample while mass-producing it, weakening its effects.

Magik and Wolverine are requested by their fellow X-Man, Storm, to assist her in finding Dahlia, a mutant orphan who has gone missing.

After helping them defeat vampyres while investigating the orphanage where Dahlia last stayed, Storm joins the Midnight Suns and aids them in their quest while continuing her search.

Eventually, they locate Dahlia in New York's sewers, where she lives alongside the Morlocks, mutants with monstrous appearances who were rejected by society and refused to join the X-Men.

Following a lengthy investigation, Blade, Deadpool, Venom, Morbius, and Storm travel to Dracula's castle to kill him and end the vampyre threat.

[14] Nico Minoru is voiced by Lyrica Okano, who reprises her role from the Marvel Cinematic Universe television series Runaways.

2K, Firaxis, and Marvel worked to create a playable build of the first act of the game within 24 hours and brought it to Wiltshire to play before he died.