She lived at the McLean County Home for Colored Children with her two older siblings from 1930 to 1942, after her mother's death and her father's unemployment during the Great Depression.

She recounted in a later interview that when news that she was becoming Catholic got to the president of the board of the McLean County Home for Colored Children, she was told that she could no longer live there.

[5] A public health nurse from Fairview brought her to Holy Trinity High School and to a local family.

[8] As a religious sister, Ebo pursued further education, earning a bachelor's degree in medical record library science from Saint Louis University in 1962,[6] and two master's degrees, one in hospital executive development (1970) from Saint Louis University, and one in theology of health care (1978) from Aquinas Institute of Theology.

[9] With encouragement from her mother superior,[15][16] Ebo and five other nuns joined the Martin Luther King's march in Selma in 1965,[17] wearing their orders' full habits.

In 1967, her religious superiors were unwilling to provide a short-term release from duties to enable her to accept an assignment with the National Catholic Conference for Interracial Justice (NCCIJ).

She served on the Human Rights Commission of the Archdiocese of St. Louis, and was a member of the Missouri Catholic Conference on Social Concerns.

[9] In 1999, she received the Eucharist from Pope John Paul II, in a group of congregants including Rosa Parks, when the pontiff visited St. Louis.

[9] The Missouri History Museum celebrated her in July of 2017 as part of an exhibit entitles, #1 in Civil Rights: The African-American Freedom Struggle in St.