She was the first woman to earn a degree from Buffalo Medical College, the first female member of the American Association of Anatomists, and one of the first women to practice medicine in New Haven, Connecticut.

Her home there is listed on the National Register of Historic Places as the Dr. Mary B. Moody House.

[3] The couple moved to Buffalo, where Lucius entered the insurance business, and eventually they had seven children.

[2] During her marriage, Moody continued her studies, attending Woman's Medical College of Pennsylvania, but illness and the needs of her family prevented completion of her degree.

[6] Moody and her family moved to New Haven, Connecticut, in 1886 where her husband ran the state office for the Northwestern Mutual Life Insurance Company.

[9] Moody died in New Haven on August 18, 1919, at age 82[7] and was buried at Spring Forest Cemetery in Broome County, New York, near where she was born.

Her long-time home in New Haven has been preserved as the Dr. Mary B. Moody House and was listed on the National Register of Historic Places in 2017.