Mary Jo McGuire (born July 29, 1956) is an American politician and former member of the Minnesota Senate who represented District 66, which included portions of Ramsey County in the Twin Cities metropolitan area.

[2] A Democrat, McGuire is an attorney and an adjunct professor in the Master of Arts in Organizational Leadership and Political Science departments at St. Catherine University in Saint Paul, and the state director for Project Citizen, a part of the Learning Law and Democracy Foundation.

A DFL Primary was held on March 29, 2011, with McGuire challenging District 66A Rep. John Lesch and attorney Steven Marchese.

[13] A lifelong resident of Falcon Heights, McGuire graduated from Alexander Ramsey High School in Roseville, then went on to the College of St. Catherine, receiving her BA in Business Administration in 1978.

[14] After graduating, she served as a criminal investigator with the Saint Paul City Attorney's Office, and was the director of the Neighborhood Mediation Project.