She was elected as leader of the Liberal Party in the Legislative Council in December 2014 and appointed as the Shadow Minister for Health.

In May 2006 she was preselected as the Liberal candidate for the seat of Doncaster to replace retiring member Victor Perton, and was elected to the Parliament of Victoria in November 2006.

She was Shadow Minister for Mental Health, Drug Abuse, Community Services and Environment and Climate Change.

In April 2010, she said the Opposition "strongly supported" the council's plans to extend the number 48 tram to the rapidly developing Doncaster Hill precinct.

When Denis Napthine replaced Baillieu as Premier, Wooldridge also became Minister for Disability Services and Reform, ceding the Women's Affairs portfolio to Heidi Victoria.

The Court was designed to assist families whose children have been placed in out of home care due to parental substance misuse.

Wooldridge also legislated secondary supply laws which prohibited serving alcohol in a private residence to minors, without their parents’ permission.

The Inquiry Panel made 90 recommendations for measures to reduce the incidence and negative impact of child abuse and neglect in Victoria in ten major system reform areas.

Commencing with an Initial trial site in Barwon, the NDIS rollout required significant investment and reform to the disability portfolio.

[22] "By ripping $20 million out of Peter Mac, Daniel Andrews is cruelly affecting the treatment and survival of thousands of Victorians with cancer," Wooldridge has said.

[24] Wooldridge announced her intention to retire from state politics on 8 December 2019, using the moment to call on the Liberal Party to consider gender quotas as a way of increasing female representation in the Victorian Parliament.