Maryknoll School is a private, coeducational Catholic school serving children in kindergarten through twelfth grade in Honolulu, Hawaiʻi.

The school is located on the island of Oʻahu and is administered by the Diocese of Honolulu in association with its original founders, the Maryknoll Society of brothers and priests and the Maryknoll Congregation also called the Maryknoll Sisters.

The school started out as a one-story wood-frame building containing four classrooms.

It was blessed and dedicated in 1927 and opened with a student body of 93 boys and 77 girls in the lower grade levels.

In 1931, the Maryknoll Sisters expanded the school to accommodate older students; in 1935, Maryknoll School graduated its first class.