The state highway also provides the primary route between Interstate 95 (I-95) and Aberdeen Proving Ground.

Another section of highway between Aberdeen and Havre de Grace, the Post Road, was also built in the early 1910s.

Churchville Road continues west as unsigned MD 922E, which intersects Bond Street, which carries southbound MD 924 and US 1 Business; the business route leaves downtown Bel Air to the west on Churchville Road.

[3] The state highway passes through the hamlet of Schucks Corner and intersects Thomas Run Road, which leads to Thomas Run Park, Harford Technical High School, Thomas Run Church, Medical Hall Historic District, and the historic Hays-Heighe House on the campus of Harford Community College.

After meeting the west end of MD 155 (Level Road) immediately to the east, the state highway curves to the south.

Immediately east of I-95, the state highway enters the city limits of Aberdeen and intersects Beards Hill Road.

East of the railroads, the highway intersects Post Road, which heads north as another section of MD 132 (officially MD 132B), before reaching its eastern terminus at Bel Air Avenue just west of an entrance to Aberdeen Proving Ground.

The highway was part of the original main road from Baltimore to Aberdeen and Havre de Grace that passed through Bel Air.

The original construction did not include the portions of Bel Air Avenue and the Post Road within the limits of Aberdeen.

[9] By 1920, the road was part of the Capitol Trail,[10] an auto trail linking Atlanta and Philadelphia via Washington, D.C.[11] MD 22 was widened to 17 feet (5.2 m) with the addition of 3-foot (0.91 m) wide concrete shoulders around 1926, just before the highway became one of the original state-numbered highways in 1927.

[14] US 40 was relocated from the Post Road to its present alignment from Aberdeen to Havre de Grace between 1930 and 1933.

[25][26] MD 22 was expanded to a four-lane divided highway from the I-95 overpass west to Long Drive in 2004 concurrent with the transformation of the original diamond interchange with I-95 to a partial cloverleaf with collector-distributor lanes.