A member of the governing People's Action Party (PAP), he has been serving as Minister for Social and Family Development and Second Minister for Health since 2020, Minister-in-charge of Muslim Affairs and serves as the Vice Chairman in the party Central Executive Committee (CEC) since 2018 and had been the Member of Parliament (MP) representing the Tampines West division of Tampines GRC since 2006.

He made his debut in the political scene after winning the 2006 general election as part of a five-member PAP team contesting in Tampines GRC.

In 1995, he completed a Master of Business Administration at the University of Southern California on a postgraduate scholarship awarded by Singtel.

[3] Masagos made his debut in politics in the 2006 general election when he contested as part of a five-member People's Action Party team in Tampines Group Representation Constituency (GRC).

[6] Masagos also said that he was honoured to have been appointed and that "[h]aving two Malay full ministers in the Cabinet for the first time in our nation's history reflects the [Government's] trust and recognition of the good progress made by the Malay-Muslim community".