CMS' successor, the Anglican Church of Kenya (ACK) remains the current sponsor of the school, overseen by the Diocese of Maseno South.

In 1905, Willis was sent to explore the Kavirondo or lake region of Kenya as a prospective place for the establishment of a mission.

After touring the area Willis pitched tent under a Hickory tree (Carya ovalis) known in the local languages as oseno (Luo) and omseno (Luhya).

Besides reading and writing, students were taught various skills such as carpentry, tailoring, printing, building, telegraphy and clerical work.

This is what happened, for instance, to BA Ohanga, later the first African to be appointed a minister in the colonial government, who was prevailed upon by Edward Carey Francis to go back to the school and teach.

[11] Most of the old structures built in the early 20th century still stand to-date even though a number of new modern ones have since been put up to keep up with the times and handle the burgeoning student population.

[16][17] School alumni can join the Maseno Old Boys Association (MOBA)[18] and has been involved in various charitable causes[19] as well as infrastructure development.

Owino took over from Andrew Buop who was posted to the United States to serve in the country's diplomatic mission as an education attache.

[21] Stansfield implemented various reforms which included variation of diet and helped construct a swimming pool at the mission.

HC Hitchen was the shortest-serving principal at Maseno School with his tenure lasting just 10 months before he left to start what is now Butere Girls.

Edward Carey Francis, came to Kenya as a missionary and teacher from Cambridge UK and the colonial office helped secure him a job as headmaster at Maseno School in December 1927.

[22] Carey Francis famously caned his then student and Kenya's future first Vice-President, Oginga Odinga, for stealing paraffin, as outlined in the latter's autobiography.

BL Bowers,[25] who served for 18 years as principal remains the longest-serving head teacher in the history of the school.

Paul Otula Complex, a dormitory popularly known as "POC" by the students and the latest at the school, is named after him.